Microbial Technology - The missing link in Modern Agriculture and Medicine

Overview:

  • Antimicrobial Cocktails are effective against antibiotic-resistant superbugs.

  • Food cultivated with microbial technologies has higher nutritional values that coffer health benefits to the animals that eat them.

  • Food cultivated with microbial technologies would have a lower level of fungal toxins that are carcinogenic and immunosuppressive.

  • Beneficial microorganisms also degrade pesticides and herbicides effectively and have far lower residual chemicals in our vegetables and fruits

  • Beneficial Microorganisms administered would boost our immune system with stronger virus-and-cancer-fighting ability.

  • Beneficial Microorganisms exert protective effects from pathogen lipopolysaccharide-induce damage. Lipopolysaccharide (LPS) is an endotoxin which may be found in very small quantity in tap water

  • Beneficial Microorganisms also exert protective effects against mycotoxins that are in our agricultural products.

  • Microbial Technologies reduce Environmental pollutions.

Introduction

The role of Natural Microorganisms in Agriculture, Herbal Plant Horticulture, and Environmental Protection is not unheard of but has gained little momentum over the years. Microbial Technology in Polyculture can be highly complicated and hard to manage in Nature. The characteristics we learn of a specific microorganism in the laboratory may not be true for it in nature. Nevertheless, this should not deter us from bringing beneficial microbiology into Agriculture and Livestock and the Waste Industry.

Picture on top: Antimicrobial Cocktail from a Consortium of many Beneficial Microorganisms inhibit pathogenic Gram-negative Bacteria Conducted at my Last Job in the USA

Picture on the right: You may click to save the picture with higher resolution. This laboratory analysis shows that, despite the disregard of temperature control which could result in pathogen overgrowth, our compost treated with beneficial microorganisms remain clean with no Salmonella and Fecal Coliforms. Additional Test showed that the compost was teaming with other beneficial microorganisms when cultivated on non-selective agar.

(According to California Code of Regulations, CCR Title 14, Chapter 3.1, Article 5., Section 17868.3.b.1, acceptable level of Fecal Coliform was 1000 MPN/g.)

At my first job after graduation, we discovered that beneficial microorganisms work together in nature against what was known as pathogens. For instance, many Lactic Acid Bacteria can co-exist with non-pathogenic E. coli but inhibits the pathogenic strains such as E. coli O157 or the Shiga toxin-producing E. coli (STEC) or simply mitigate the negative effects of these pathogenic microorganisms. 

 

“Good Microbes vs Bad Microbes”

More interestingly, Beneficial Microorganisms are capable of “exerting” a behavioral influence on potentially pathogenic microorganisms. Dr Rutherford and Dr Bassler from Princeton University were some of the pioneering researchers in Quorum sensing of microorganisms where they learn that microorganisms can communicate and keep one another in check. When the ‘bad guys’ are in the minority, they are capable of KNOWING they are in the minority and they behave well. Take out the good bacteria, the bad guys will KNOW and they start to wreak havoc in our system.

“Good Microbes work with Herbal Plants against Bad Microbes”

Then interestingly, this “intelligence” in microorganisms is far-reaching to plants and the human host. Having again, the same “friends or foes” recognizing ability and capable of working symbiotically to confer health to the consumer. In fact, the use of herbal plants helps beneficial microorganisms to get established in our gut system and bringing about many therapeutic benefits.

A Clinical Trial conducted by a group of Korean Doctors, in December of 2017, shows the use of fermented milk containing Lactobacillus paracasei and Licorice root with a beneficial effect in patients with H. pylori infection. It will take years and entrepreneurs to make these technologies available to the public.

“Microorganisms in Agriculture and Human Immune System”

Besides direct therapeutic benefits to the human host, microbial technology in agriculture also improves the quality of the plants, which helps to build a strong immune system.

References:

  1. Ammoscato F1, Scirocco A, Altomare A, Matarrese P, Petitta C, Ascione B, Caronna R, Guarino M, Marignani M, Cicala M, Chirletti P, Malorni W, Severi C. Lactobacillus rhamnosus protects human colonic muscle from pathogen lipopolysaccharide-induced damage.Neurogastroenterol Motil. 2013 Dec;25(12):984-e777. doi: 10.1111/nmo.12232. Epub 2013 Oct 1.

  2. Anderson WB, Huck PM, Dixon DG, Mayfield CI. Endotoxin Inactivation in Water by Using Medium-Pressure UV Lamps. Applied and Environmental Microbiology May 2003, 69 (5) 3002-3004; DOI: 10.1128/AEM.69.5.3002-3004.2003

  3. Arai S, Iwabuchi N, Takahashi S, Xiao JZ, Abe F, Hachimura S. Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice. PLoS One. 2018 Jun 13;13(6):e0199018. doi: 10.1371/journal.pone.0199018. eCollection 2018.

  4. Aziz N, Bonavida B. Activation of Natural Killer Cells by Probiotics. For Immunopathol Dis Therap. 2016;7(1-2):41‐55. doi:10.1615/ForumImmunDisTher.2016017095

  5. Davoodabadi A, Soltan Dallal MM, Lashani E, Tajabadi Ebrahimi M. Antimicrobial Activity of Lactobacillus spp. Isolated From Fecal Flora of Healthy Breast-Fed Infants Against Diarrheagenic Escherichia coli. Jundishapur J Microbiol. 2015;8(12):e27852. Published 2015 Dec 26. doi:10.5812/jjm.27852

  6. Deep A, Chaudhary U, Gupta V. Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease. J Lab Physicians. 2011;3(1):4‐11. doi:10.4103/0974-2727.78553

  7. Johnson-Henry KC, Donato KA, Shen-Tu G, Gordanpour M, Sherman PM. Lactobacillus rhamnosus Strain GG Prevents Enterohemorrhagic Escherichia coli O157:H7-Induced Changes in Epithelial Barrier Function. Infection and Immunity Mar 2008, 76 (4) 1340-1348; DOI: 10.1128/IAI.00778-07

  8. Rutherford ST, Bassler BL. Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med. 2012;2(11):a012427. Published 2012 Nov 1. doi:10.1101/cshperspect.a012427

  9. Yoon, Jin Young MD, PhDa; Cha, Jae Myung MD, PhDa,∗; Hong, Seong Soo MD, PhDb,∗; Kim, Hyung Kyung MD, PhDc; Kwak, Min Seob MD, PhDa; Jeon, Jung Won MD, PhDa; Shin, Hyun Phil MD, PhDa Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection, Medicine: August 2019 - Volume 98 - Issue 35 - p e16601 doi: 10.1097/MD.0000000000016601

Understanding the Challenges in Agriculture

The average person living in the Modern World may have a suppressed immune system due to the toxins we are exposed to from day-to-day. A common one is the low level of mycotoxins in food such as coffee, corn, and many other grains grown in Modern Agricultural Technology. This can be addressed if beneficial microorganisms are introduced into our Agricultural System.

Mycotoxins such as Aflatoxins will lower your T cells that are responsible for fighting viral infection and cancer cells. Do not be surprised by the increasing rate of cancer today. This has much to do with our suppressed immune system.

Besides fungal toxin, Modern Agriculture's emphasis on yield and not the nutritional quality of the plants is another serious problem. The neglect of soil quality and the neglect of the importance of trace minerals and soil carbon content are the many reasons why our food has lower nutritional value today. 

This is especially obvious with Herbal Plant Cultivation, the use of chemical fertilizers is doing great damage to the Alternative Medicine Industry. 

 

Conventional Agriculture treats our plants like laboratory specimens which we try to create a relatively clean environment void of pests and competing plants with only ONE GOAL in mind, maximum yield. If possible, we would try to grow them in sterile media so that the plants invest far less energy in immune defense but for growth.

But stress is beneficial since it elicits the biosynthesis and accumulation of many bioactive compounds with therapeutic potentials in plants.

 

However, incorrect stress-induction can result in a drastic loss of crop yield, but it is still possible to maintain high yield with quality, the secret lies in microbial technology in soil. 

 

The ones with microbial inoculation clearly have larger root mass, while the NPK and Control have smaller root mass. Plants that have chemical fertilizer and Microbial Inoculation perform extraordinarily well compared to just the microorganisms alone. Although the test focused mainly on shoot and root growth, it is necessary to understand that, the medicinal value of many herbal plants is actually in the root. 

References:

  1. Author: Unknown. Dirt Poor: Have Fruits and Vegetables Become Less Nutritious? Environment, Scientific American. April 27. 2011. https://www.scientificamerican.com/article/soil-depletion-and-nutrition-loss/

  2. Author:Unknown. It's supposed to be lean cuisine. So why is this chicken fatter than it looks? The Guardian. Food/The Observer. Mon 16 May 2005. Site: https://www.theguardian.com/lifeandstyle/2005/may/15/foodanddrink.shopping3

  3. Howitz, KT. Sinclair, D. Xenohormesis: Sensing the Chemical Cues of Other Species.  Cell. 2008 May 2;133(3):387-91. doi: 10.1016/j.cell.2008.04.019.

  4. Toscano, S., Trivellini, A. and Ferrante, A. Effect of Preharvest Abiotic Stresses on the Accumulation of Bioactive Compounds in Horticultural Produce. Front Plant Sci. 2019;10: 1212

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